There are a lot of female ninjas in Naruto Online. I like to collect female ninjas in the game. In the anime, there are quite a few powerful characters.
I think, Naruto has always been the strongest Hokage but of course, this is only my opinion.
In the Naruto anime, Tsunade is probably the most powerful medical-nin. A few plots can attest to this point in game mmorpg online.